InterPAD - DETAILS

(+)-ursolic acid, (3 beta)-3-hydroxyurs-12-en-28-oic acid, 3 Epi Ursolic Acid, 3 Epiursolic Acid, 3-epi-ursolic acid, 3-epiursolic acid, 3alpha Ursolic Acid, 3alpha-ursolic acid, 3beta Ursolic Acid, 3beta-ursolic acid, Merotaine, olean-12-en-28-oic acid, 3-hydroxy-, sodium salt (1:1), (3beta)-, Oleanolate, Sodium, sodium oleanolate, ursolic acid, ursolic acid monosodium salt, ursolic acid sodium salt, ursolic acid, (3beta)-isomer, 2-(14)C-labeled, ursolic acid, (3beta)-isomer, monopotassium salt

No.	Title	Href
1	Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer. Pharmacol Res. 2022 Aug;182:106306. doi: 10.1016/j.phrs.2022.106306.	`Click`
2	Ursolic Acid Enhances the Sensitivity of MCF-7 and MDA-MB-231 Cells to Epirubicin by Modulating the Autophagy Pathway. Molecules. 2022 May 25;27(11):3399. doi: 10.3390/molecules27113399.	`Click`
3	Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction. Biochem Pharmacol. 2022 Nov;205:115278. doi: 10.1016/j.bcp.2022.115278.	`Click`
4	Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells. Pharmazie. 2020 Jun 1;75(6):246-249. doi: 10.1691/ph.2020.0417.	`Click`
5	Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro. Oncol Rep. 2016 Jul;36(1):428-40. doi: 10.3892/or.2016.4813.	`Click`
6	Synergism of ursolic acid and cisplatin promotes apoptosis and enhances growth inhibition of cervical cancer cells via suppressing NF-κB p65. Oncotarget. 2017 Oct 30;8(57):97416-97427. doi: 10.18632/oncotarget.22133.	`Click`
7	Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway. Mol Med Rep. 2023 Jan;27(1):11. doi: 10.3892/mmr.2022.12898.	`Click`
8	Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib. Colloids Surf B Biointerfaces. 2024 Feb;234:113724. doi: 10.1016/j.colsurfb.2023.113724.	`Click`
9	Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance. Cancer Sci. 2018 Jan;109(1):94-102. doi: 10.1111/cas.13425.	`Click`
10	Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. Drug Des Devel Ther. 2016 Oct 25;10:3471-3481. doi: 10.2147/DDDT.S110505.	`Click`

No.

Title

Href

Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer. Pharmacol Res. 2022 Aug;182:106306. doi: 10.1016/j.phrs.2022.106306.

Click

Ursolic Acid Enhances the Sensitivity of MCF-7 and MDA-MB-231 Cells to Epirubicin by Modulating the Autophagy Pathway. Molecules. 2022 May 25;27(11):3399. doi: 10.3390/molecules27113399.

Click

Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction. Biochem Pharmacol. 2022 Nov;205:115278. doi: 10.1016/j.bcp.2022.115278.

Click

Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells. Pharmazie. 2020 Jun 1;75(6):246-249. doi: 10.1691/ph.2020.0417.

Click

Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro. Oncol Rep. 2016 Jul;36(1):428-40. doi: 10.3892/or.2016.4813.

Click

Synergism of ursolic acid and cisplatin promotes apoptosis and enhances growth inhibition of cervical cancer cells via suppressing NF-κB p65. Oncotarget. 2017 Oct 30;8(57):97416-97427. doi: 10.18632/oncotarget.22133.

Click

Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway. Mol Med Rep. 2023 Jan;27(1):11. doi: 10.3892/mmr.2022.12898.

Click

Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib. Colloids Surf B Biointerfaces. 2024 Feb;234:113724. doi: 10.1016/j.colsurfb.2023.113724.

Click

Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance. Cancer Sci. 2018 Jan;109(1):94-102. doi: 10.1111/cas.13425.

Click

Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. Drug Des Devel Ther. 2016 Oct 25;10:3471-3481. doi: 10.2147/DDDT.S110505.

Click

Name	Ursolic acid
PubChem CID	64945
Molecular Weight	456.7g/mol
Synonyms	(+)-ursolic acid, (3 beta)-3-hydroxyurs-12-en-28-oic acid, 3 Epi Ursolic Acid, 3 Epiursolic Acid, 3-epi-ursolic acid, 3-epiursolic acid, 3alpha Ursolic Acid, 3alpha-ursolic acid, 3beta Ursolic Acid, 3beta-ursolic acid, Merotaine, olean-12-en-28-oic acid, 3-hydroxy-, sodium salt (1:1), (3beta)-, Oleanolate, Sodium, sodium oleanolate, ursolic acid, ursolic acid monosodium salt, ursolic acid sodium salt, ursolic acid, (3beta)-isomer, 2-(14)C-labeled, ursolic acid, (3beta)-isomer, monopotassium salt
Formula	C₃₀H₄₈O₃
SMILES	CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O
InChI	1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChIKey	WCGUUGGRBIKTOS-GPOJBZKASA-N
CAS Number	77-52-1
ChEMBL ID	CHEMBL169
ChEBI ID	CHEBI:9908
Drug Bank ID	DB15588
KEGG ID	C08988
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	GanSong
Use Part	Root, Rhizome
Habitat	GanSu, QingHai, SiChuan
Flavor	Pungent, Sweet
Meridian Tropism	Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Dipsacales 　　　　-->Family: Caprifoliaceae 　　　　　-->Genus: Nardostachys 　　　　　　-->Species: Nardostachys chinensis

Chineses Pinyin	LingLingXiang
Use Part	Whole Grass With Root
Habitat	HuNan, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan
Flavor	Pungent, Sweet
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ericales 　　　　-->Family: Primulaceae 　　　　　-->Genus: Lysimachia 　　　　　　-->Species: Lysimachia foenum-graecum

Chineses Pinyin	CheQianCao
Use Part	Seed
Habitat	China
Flavor	Sweet
Meridian Tropism	Liver, Kidney, Lung, Small intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Plantaginaceae 　　　　　-->Genus: Plantago 　　　　　　-->Species: Plantago depressa

Chineses Pinyin	BanZhiLian
Use Part	Whole Grass
Habitat	GuangDong, ZheJiang, FuJian, TaiWan, GuangXi, HaiNan
Flavor	Pungent, Bitter
Meridian Tropism	Lung, Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Scutellaria 　　　　　　-->Species: Scutellaria barbata

Chineses Pinyin	BoHe
Use Part	Aerial Parts
Habitat	JiangSu
Flavor	Pungent
Meridian Tropism	Lung, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Mentha 　　　　　　-->Species: Mentha haplocalyx

Chineses Pinyin	DongLingCao
Use Part	Whole Grass
Habitat	HeNan, HeBei, ShanXi, GanSu, SiChuan, GuiZhou, HuNan, HuBei, GuangXi, GuangDong, JiangXi, AnHui, ZheJiang
Flavor	Bitter, Sweet
Meridian Tropism	Lung, Stomach, Liver

Chineses Pinyin	DuanXueLiu
Use Part	Aerial Parts
Habitat	HeBei, HeNan, ShanDong, ShanXi, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, TaiWan, HuBei, HuNan, GuangXi, Shaanxi, GanSu, YunNan, GuiZhou, SiChuan, XiZang
Flavor	Mildly bitter, Astringent
Meridian Tropism	Liver

Chineses Pinyin	JingJieSui
Use Part	Dried Flower Spike
Habitat	XinJiang, GanSu, Shaanxi, HeNan, ShanXi, ShanDong, HuBei, GuiZhou, SiChuan, YunNan
Flavor	Pungent
Meridian Tropism	Lung, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Schizonepeta 　　　　　　-->Species: Schizonepeta tenuifolia

Chineses Pinyin	JingJieSuiTan
Use Part	Dried Flower Spike Carbon Products
Habitat	XinJiang, GanSu, Shaanxi, HeNan, ShanXi, ShanDong, HuBei, GuiZhou, SiChuan, YunNan
Flavor	Pungent, Astringent
Meridian Tropism	Lung, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Schizonepeta 　　　　　　-->Species: Schizonepeta tenuifolia

Chineses Pinyin	LianQianCao
Use Part	Whole Grass
Habitat	China
Flavor	Pungent, Mildly bitter
Meridian Tropism	Liver, Kidney, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Glechoma 　　　　　　-->Species: Glechoma longituba

Chineses Pinyin	XiaKuCao
Use Part	Spike
Habitat	China
Flavor	Pungent, Bitter
Meridian Tropism	Liver, Gallbladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Prunella 　　　　　　-->Species: Prunella vulgaris

Chineses Pinyin	ZeLan
Use Part	Aerial Parts
Habitat	HeiLongJiang, JiLin, LiaoNing, HeBei, Shaanxi, GuiZhou, YunNan, SiChuan
Flavor	Bitter, Pungent
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Lycopus 　　　　　　-->Species: Lycopus lucidus

Chineses Pinyin	GouGuYe
Use Part	Leaf
Habitat	HuBei, JiangXi, AnHui, JiangSu, ZheJiang, ShangHai, HuNan
Flavor	Bitter
Meridian Tropism	Liver, Kidney

Chineses Pinyin	SiJiQing
Use Part	Leaf
Habitat	HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor	Bitter, Astringent
Meridian Tropism	Lung, Large intestine, Bladder

Pair Name	Ursolic acid, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Up-regulation	Expression	BIM	hsa10018
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Expression	PARP1	hsa142
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	SLC7A11	hsa23657
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
In Vivo Model	HCT 116 cells (3×10⁶), HCT116 Vector cells (3×10⁶), HCT116 Mcl-1 overexpression cells (3×10⁶) and HCT116 SLC7A11 overexpression cells (3×10⁶) suspended in 0.2 ml of PBS were subcutaneously inoculated into the right flank of each mouse.
Result	These results suggest that the synergistic antitumor effects of sorafenib combined with ursolic acid may involve the induction of Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis. Our findings may offer a novel effective therapeutic strategy for tumor treatment.

Pair Name	Ursolic acid, Epirubicin
Partner Name	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Up-regulation	Expression	ATG5	hsa9474
	Up-regulation	Expression	ATG7	hsa10533
	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Expression	PIK3CA	hsa5290
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	These findings indicate that UA can dramatically enhance the sensitivity of MCF-7 and MDA-MB-231 cells to EPI by modulating the autophagy pathway. Our study may provide a new therapeutic strategy for combination therapy.

Pair Name	Ursolic acid, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Expression	PPARGC1A	hsa10891
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	SLC2A1	hsa6513
In Vitro Model	NCI-ADR-RES	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_1452
Result	Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction

Pair Name	Ursolic acid, Oxaliplatin
Partner Name	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	RKO	Colon carcinoma	Homo sapiens (Human)	CVCL_0504
Result	These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment.

Chineses Pinyin	GanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu, GanSu, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	HongQi
Use Part	Root
Habitat	NeiMengGu, NingXia, GanSu, SiChuan
Flavor	Sweet
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Hedysarum 　　　　　　-->Species: Hedysarum polybotrys

Chineses Pinyin	JiGuCao
Use Part	Whole Grass
Habitat	GuangXi, GuangDong
Flavor	Sweet, Mildly bitter
Meridian Tropism	Liver, Stomach

Chineses Pinyin	ZhiGanCao
Use Part	Root, Rhizome Of Prepared Liauorice Root
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, XinJiang, ShanDong
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	ZhiHongQi
Use Part	Root Of Prepared Manyinflorescenced Sweetvetch Root
Habitat	GanSu, SiChuan, Shaanxi, GanSu, QingHai, NingXia, XinJiang
Flavor	Sweet
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Hedysarum 　　　　　　-->Species: Hedysarum polybotrys

Chineses Pinyin	ManShanHong
Use Part	Leaf
Habitat	HeiLongJiang, JiLin, XinJiang
Flavor	Pungent, Bitter
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ericales 　　　　-->Family: Ericaceae 　　　　　-->Genus: Rhododendron 　　　　　　-->Species: Rhododendron dauricum

Chineses Pinyin	DaZao
Use Part	Ripe fruit
Habitat	HeNan, HeBei, ShanDong
Flavor	Sweet
Meridian Tropism	Spleen; Stomach; Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rhamnaceae 　　　　　-->Genus: Ziziphus 　　　　　　-->Species: Ziziphus jujuba

Pair Name	Ursolic acid, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Inhibition-->Cell proliferation
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
Gene Regulation	Down-regulation	Expression	HIF1A	hsa3091
In Vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1α and ABCG2.